A modular framework for gene set analysis integrating multilevel omics data
نویسندگان
چکیده
منابع مشابه
A modular framework for gene set analysis integrating multilevel omics data
Modern high-throughput methods allow the investigation of biological functions across multiple 'omics' levels. Levels include mRNA and protein expression profiling as well as additional knowledge on, for example, DNA methylation and microRNA regulation. The reason for this interest in multi-omics is that actual cellular responses to different conditions are best explained mechanistically when t...
متن کاملRAMONA: a Web application for gene set analysis on multilevel omics data
SUMMARY Decreasing costs of modern high-throughput experiments allow for the simultaneous analysis of altered gene activity on various molecular levels. However, these multi-omics approaches lead to a large amount of data, which is hard to interpret for a non-bioinformatician. Here, we present the remotely accessible multilevel ontology analysis (RAMONA). It offers an easy-to-use interface for ...
متن کاملmogsa: gene set analysis on multiple omics data
2 Run mogsa 1 2.1 Quick start . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2.2 Result analysis and interpretation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2.3 Plot gene sets in projected space . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2.4 Perform MOGSA in two steps ....
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The challenge for -omics research is to tackle the problem of fragmentation of knowledge by integrating several sources of heterogeneous information into a coherent entity. It is widely recognized that successful data integration is one of the keys to improve productivity for stored data. Through proper data integration tools and algorithms, researchers may correlate relationships that enable t...
متن کاملMulti-Omics Data Integration: A Modular Approach
Substantial extent of research has been carried out over past few decades to understand the molecular and genetic level information within the cell that help improving the methodologies in the fields of agricultural or medical research. However, often the research is focused at one particular area of expertise by an individual researcher or a work group and very less number of attempts were mad...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2013
ISSN: 1362-4962,0305-1048
DOI: 10.1093/nar/gkt752